Sarcomere: unit structure of muscle
A molecular approach to diastolic heart failure
Ongoing studies at the Ruhr University, Germany, are seeking new targets in the fight against diastolic heart failure. The researchers are shedding light on the elasticity of heart muscle cells.
Professor Wolfgang A. Linke is conducting groundbreaking research into titin, a large protein prevalent in the human body. Here, he talks about his 20 years’ experience in the field.Flyer made by ResearchMedia:
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Titin Research Roundup
Titin is a high-molecular weight protein (3.0-3.8 MDa) in the sarcomeres of vertebrate striated muscles. A plethora of titin isoforms is expressed from the copy of a single titin gene (on chromosome 2 in mouse and humans).
Mechanics of the Single Myofibril
The single myofibril is the minimum preparation that retains the natural architecture of the sarcomere. As such, it has some important advantages over the larger preparations that also retain the lattice.
Physiology of Cardiac and Skeletal Muscle
Recent investigations using quantitative RT-PCR and high-resolution SDS-polyacrylamide gel electrophoresis showed that the titin isoform expression pattern is modified dramatically during perinatal heart development (Opitz et al., 2004).